Vitamin B12 plays a vital role in human health, supporting everything from energy metabolism to nerve regeneration. As a key ingredient in the food supplements industry, its price and sourcing trends are closely watched by buyers around the globe.
1. Cyanocobalamin
Popular for cost-effective mass-market formulas
● Target Use in Supplements:
General B12 maintenance formulas (daily multivitamins, economy brands)
Energy support blends (with B-complex vitamins like B6, B9)
Bariatric recovery products (for post-gastric surgery patients)
Vegan nutrition support(as B12 is absent in plant-based diets)
● Typical Combinations:
B6 + B9 (folic acid) for cardiovascular support
Iron + Cyanocobalamin in women’s health SKUs
Ginseng + B-complex for energy/stress formulas
2. Methylcobalamin
Neuroactive form for cognitive and mood support formulas
● Target Use in Supplements:
Cognitive function: Focus, memory, and brain aging products
Mood regulation: Often included in stress, anxiety, and sleep blends
MTHFR gene mutation: For people needing methylated nutrients
Diabetic neuropathy formulas: Supports nerve regeneration
● Typical Combinations:
Lion’s Mane + Methylcobalamin for cognitive supplements
Magnesium + Melatonin + Methylcobalamin for sleep aids
5-HTP + Methylcobalamin in mood support
3. Hydroxocobalamin
Long-acting B12 form with clinical-grade bioavailability
● Target Use in Supplements:
Injectable nutraceuticals (under physician supervision)
Detox blends: Acts as a cyanide scavenger
Fatigue formulas in chronic fatigue syndrome (CFS)
B12 repletion for autoimmune-related deficiency (e.g., pernicious anemia)
● Typical Combinations:
Hydroxocobalamin + Glutathione in detox IV formulas
Alpha Lipoic Acid + Hydroxocobalamin for nerve support
Use in NAD+ booster regimens
4. Adenosylcobalamin
Mitochondrial coenzyme for deep cellular energy
● Target Use in Supplements:
Mitochondrial support: Products aimed at chronic fatigue, ME/CFS
Sports recovery: Muscle metabolism and endurance
Anti-aging and cellular repair: DNA synthesis and mitochondrial renewal
Genetic disorders: Supports patients with methylmalonic acidemia (MMA)
● Typical Combinations:
CoQ10 + Adenosylcobalamin + PQQ for mitochondrial blends
NADH + Adenosylcobalamin in cellular energy products
Cordyceps + Adenosylcobalamin in performance enhancement supplements
As of May 2025, the market price of Vitamin B12 has dropped to its lowest point since 2023, As one of the key vitamins used in food supplements, this price movement presents an excellent opportunity for manufacturers, formulators, and health brands to secure their supply at a competitive rate. If you have any upcoming demand, this is an ideal window for procurement.
Swiftbond Biotechnology is a trusted supplier of vitamins and food supplement ingredients, delivering premium nutritional solutions at the most competitive prices. For more information, please click here to request a quote.