What Is Spermidine?
Spermidine is a natural polyamine compound mainly derived from germinated wheat (Triticum aestivum).
It plays a key role in cell growth, renewal, and longevity by supporting a process called autophagy — the body’s natural cellular cleansing system.
How is Spermidine absorbed in the human body?
Spermidine from shandong swiftbond, a naturally occurring polyamine, plays a vital role in cellular renewal and autophagy. When taken as a dietary supplement—especially from germinated wheat extract standardized to 1%—it must be efficiently absorbed to exert its biological benefits.
After oral ingestion, Spermidine begins releasing in the stomach under mildly acidic conditions (around pH 2–4). Studies indicate that Spermidine remains chemically stable in normal gastric environments, allowing partial absorption through the stomach lining.
The majority of absorption, however, occurs in the small intestine, where the pH gradually rises to 6–7.5. This environment supports optimal Spermidine release and transport across intestinal cells (enterocytes), ensuring it reaches the bloodstream and subsequently distributes to vital organs such as the liver, brain, and heart.
Overall, Spermidine demonstrates dual-site absorption—beginning in the stomach and continuing through the small intestine—making it a stable and effective ingredient for nutritional and anti-aging formulations.
Does capsule type affect its stability and bioavailability?
Standard Vegetable Capsules (HPMC):
● Dissolve quickly in the stomach (pH 1–3).
● Suitable for stable ingredients such as Spermidine.
● Provide efficient and cost-effective delivery.
Enteric Vegetable Capsules (Gastroresistant HPMC):
● Remain intact in stomach acid and dissolve only in the small intestine (pH ≥ 6).
● Offer extra protection for acid-sensitive ingredients.
● Ideal for premium product positioning.
Conclusion
For Spermidine, standard Vegetable Capsules (HPMC) already ensure effective absorption in the small intestine. Enteric HPMC capsules can be an optional upgrade for brands that emphasize high-end formulation and targeted release.
About SHANDONG SWIFTBOND BIOTECHNOLOGY
SHANDONG SWIFTBOND BIOTECHNOLOGY specializes in botanical extracts (herbal extract) and nutraceutical raw materials. We also provide finished product solutions, including formulation and capsule development, to help brands deliver effective and market-ready supplements.
Our Spermidine (standardized extract from wheat germ, 1%) is GMO-Free, Gluten-Free, and Vegan, produced under GMP/ISO-certified conditions. Please click here to request a quote and we promise to help you through your manufacturing journey.